Publications

Peer-reviewed research and technical publications advancing high-content C. elegans screening, microfluidics, imaging, and New Approach Methodologies.

C. elegans AI

August 3, 2026Aug 03, 2026

Machine Learning-Accelerated Analysis of In Utero Embryo Phenotyping in C. elegans for Reproductive Toxicity Assessment

Introduces EmbryoMAE-Det, a machine-learning framework that automatically detects and classifies in utero embryos for rapid, reproducible, high-content C. elegans reproductive toxicity assessment.

Research Square (Preprint) DOI
Abhishri Medewar, DuPlissis, Laing, Shen, Hegarty, Gomez, Carrion, Brown, Mondal & Ben-Yakar Medewar
C. elegans screening

July 10, 2026Jul 10, 2026

A robust, high-content NAM for repeatable and predictive developmental and reproductive toxicity assessment in C. elegans

A repeatable whole-organism DART NAM combining C. elegans, high-content imaging, microfluidics, and quantitative developmental and reproductive endpoints for predictive toxicity assessment.

Scientific Reports DOI
Sudip Mondal, Laing, Shen, Hegarty, Medewar, Gomez, Carrion, Brown, Hunt & Ben-Yakar Mondal
C. elegans screening AI

January 2, 2025Jan 02, 2025

Machine learning-based analysis of microfluidic device immobilized C. elegans for automated developmental toxicity testing

Introduces an automated machine-learning pipeline for segmenting microfluidic-immobilized worms and quantifying developmental toxicity endpoints from high-resolution images.

Scientific Reports DOI
Andrew DuPlissis, Medewar, Hegarty, Laing, Shen, Gomez, Mondal & Ben-Yakar DuPlissis
Microfluidics (vivoChip)

May 16, 2018May 16, 2018

High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model

Demonstrates high-content microfluidic screening in a C. elegans Alzheimer’s disease model to identify ligands that reduce age-dependent neurodegeneration.

ACS Chemical Neuroscience DOI
Sudip Mondal, Hegarty, Sahn, Scott, Gökçe, Martin, Ghorashian, Satarasinghe, Iyer, Sae-Lee, Hodges, Pierce, Martin & Ben-Yakar Mondal
Microfluidics (vivoChip)

October 11, 2016Oct 11, 2016

Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

Presents a large-scale microfluidic platform for high-resolution, high-throughput phenotyping of protein aggregation in a C. elegans polyglutamine disease model.

Nature Communications DOI
Sudip Mondal, Hegarty, Martin, Gökçe, Ghorashian & Ben-Yakar Mondal
C. elegans flow cytometry

October 29, 2018Oct 29, 2018

Line excitation array detection fluorescence microscopy at 0.8 million frames per second

Describes an ultrafast fluorescence microscopy approach capable of imaging at 0.8 million frames per second for high-throughput analysis of rapidly moving biological samples.

Nature Communications DOI
Chris Martin, Li, Hegarty, Zhao, Mondal & Ben-Yakar Martin
Reviews

January 2019Jan 01, 2019

High-Content and High-Throughput In Vivo Drug Screening Platforms Using Microfluidics

Reviews microfluidic technologies that enable high-content, high-throughput in vivo drug screening and bridge whole-organism biology with scalable experimental workflows.

Assay and Drug Development Technologies DOI
Adela Ben-Yakar Ben-Yakar
Book chapters

2020Sep 08, 2026

Caenorhabditis elegans-on-a-Chip: Microfluidic Platforms for High-Resolution Imaging and Phenotyping

A book chapter surveying C. elegans-on-a-chip technologies for precise microfluidic handling, high-resolution imaging, and quantitative phenotyping.

Organ-on-a-Chip DOI
Sudip Mondal & Ben-Yakar Mondal
Microfluidics (other)

August 29, 2017Aug 29, 2017

A multi-trap microfluidic chip enabling longitudinal studies of nerve regeneration in Caenorhabditis elegans

Introduces a multi-trap microfluidic device for repeatedly imaging individual C. elegans over time to study neuronal injury and regeneration longitudinally.

Scientific Reports DOI
Sertan Kutal Gökçe, Hegarty, Mondal, Zhao, Ghorashian, Hilliard & Ben-Yakar Gökçe