vivoScreen®

Automated High-Throughput, High-Content Imaging System for C. elegans Researchers

vivoScreen is a complete imaging solution enabling high-resolution imaging of C. elegans at high-throughput scales. At the heart of the system is the vivoChip-24x, a multiwell plate format microfluidic device that can immobilize and laterally align up to 40 C. elegans from 24 different populations for high-resolution imaging, for a total of nearly 1,000 whole-organisms in a single imaging session. When combined with the fully motorized microscope and intuitive experiment design and image acquisition, the vivoScreen opens up new experimental avenues not possible with traditional microscopes or imaging systems.

Complete Imaging Workflow

Rapid, High-Content C. elegans Imaging

vivoChip-24x diagram showing the 24-population microfluidic imaging format
vivoChip-24x supports parallel imaging of 24 independently treated populations.
  • Image whole bodies of ~1,000 C. elegans from 24 populations at ~0.4 µm pixel resolution in 10 minutes using vivoImager and vivoChip-24x
  • Automatically calculate ~1,000 C. elegans lengths and volumes in 1 minute with vivoAI
  • Image a 24-well plate in 10 minutes (1 image per well) using vivoImager
  • Automatically calculate ~1,000 C. elegans aggregate counts and sizes in 2 hours with vivoAnalyzer

Plate-Reader Speeds

A Future-Proof System

While it is excellent for general research use, the standard vivoScreen build has been specialized for imaging using the microfluidic vivoChip-24x, making vivoScreen the only system capable of high-throughput and high-resolution imaging of C. elegans. Large field-of-view optics, a state-of-the-art camera, motorized components, and a modular light path make the vivoScreen imaging system both powerful enough to fulfill a wide range of daily research needs and flexible enough to evolve as research requirements change.

  • Software-controllable 6-position objective mount, 8-position fluorescence cube deck, and 7-position long-working-distance condenser turret
  • Readily accessible light path for easy changing of optical components as your research needs evolve
  • Water- and oil-immersion objective compatibility
  • Fluorescence, brightfield, DIC, and phase contrast imaging compatibility
  • Software-controllable LED light sources for instantaneous and stable illumination

Software Tools for Automated Imaging and Analysis

  • Manual and automated imaging modes with autofocus and worm detection for use with vivoChip-24x
  • Time-lapse, Z-stack, and tiling image capture options
  • Expanded protocols for imaging well plates and other standard sample vessel formats with future software updates
  • Point-and-click-based user-defined phenotype and feature identification workflows for custom assay analysis
  • Fully-automated AI-assisted analysis of supported phenotypes and features
  • Analysis output data exportable to a spreadsheet format
Automated worm body detection and analysis output

Expert help available for equipment grant applications

Major equipment grant programs are available from the NIH, NSF and others, providing substantial funding to acquire cutting-edge research instruments. The vivoScreen system is eligible for these grants and our experienced team can assist in preparing and submitting compelling grant proposals. We can prepare detailed quotes tailored to meet the specific requirements of the grant program and provide comprehensive technical documentation to strengthen your application.

~1,000Worms per imaging session
24Independent populations
~0.4 µmPixel resolution
10 minWhole-body imaging

Interested in vivoScreen? Request a Quote →