vivoChip-2x loading & immobilization

See how vivoChip^® enables rapid immobilization and alignment of multiple worms for high resolution imaging

Loading C. elegans to image PolyQ protein aggregation

C. elegans with a YFP reporter showing PolyQ protein aggregation (a worm model for Huntington’s disease) are loaded into a vivoChip for immobilization and high-resolution imaging. Immobilized worms are then imaged so the aggregates can be quantified in each animal.

Large scale phenotypic screening of chemical libraries with C. elegans

vivoVerse hosted this webinar introducing the high-throughput version of our system, the vivoChip-96x, and how it has been used for large-scale screens. Dr. Sudip Mondal of UT Austin, presents his work on high-throughput, high-content screens of chemical libraries in C. elegans, which were performed using the vivoChip-96x and integrated imaging system.

C. elegans is rapidly gaining interest as an animal alternative in vivo model for toxicology and drug candidate screening, but high-resolution imaging of the thousands of animals necessary for large phenotypic screens has been impossible with existing technology. Dr. Mondal will show how large-scale phenotypic screening was performed in the vivoChip-96x to identify compounds of interest.

High-content analysis of disease models and toxicology studies using C. elegans

vivoVerse presents a 30 minute live webinar on the applications of the vivoChip^® for rapid immobilization of up to 40 C. elegans within minutes and high-resolution imaging in any microscope. During this webinar, we will demonstrate how the vivoChip can accelerate researchers’ workflow in the lab and enables high-throughput and high-content studies on the following topics: High-resolution imaging of C. elegans germline in three dimensions; C. elegans for assessing developmental and reproductive toxicity; C. elegans for assessing developmental neurotoxicity

This webinar would be useful for: researchers in the C. elegans community doing high-resolution imaging or phenotypic scoring of neurons, germline cells, or other tissues; assay developers performing chemical library or RNAi screens in multiple populations; toxicologists looking for alternatives to animal models for toxicity testing; and anyone interested in finding out more about our products and services.